Email this article Acute promyelocytic leukemia presenting with basophilia: diagnostic features and clinical observation
- Authors: Akezheva K.A.1, Aleshina O.A.1, Vasileva A.N.1, Dvirnyk V.N.1, Ershov A.A.1, Obukhova T.N.1, Kovrigin A.M.1, Troitskaya V.V.1
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Affiliations:
- National Medical Research Center for Hematology
- Issue: Vol 4, No 2 (2024)
- Pages: 65-70
- Section: RARE AND COMPLEX CLINICAL SITUATIONS: DIAGNOSIS AND SELECTION OF TREATMENT TACTICS
- Published: 14.06.2024
- URL: https://mdonco.abvpress.ru/jour/article/view/116
- DOI: https://doi.org/10.17650/2782-3202-2024-4-2-65-70
- ID: 116
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Abstract
Acute promyelocytic leukemia (APL) is a blood tumor characterized by aggressive clinical progression with characteristic clinical and laboratory signs (typical tumor cell morphology, severe hemorrhagic syndrome, hemorrhages with hematoma formation, excessive fibrinolysis, disseminated intravascular coagulation syndrome) but modern approaches to therapy potentially make this disease fully curable. APL is considered one of the most studied subtypes of acute leukemia and is characterized by abnormal proliferation of promyelocytes in the bone marrow. The morphologic picture of APL is quite diverse, but an increased basophil count represents a rare manifestation that requires further study and understanding of its significance. Currently, there are limited scientific data on the clinical course and response to standard therapy in patients with APL presenting with basophilia.
About the authors
K. A. Akezheva
National Medical Research Center for Hematology
Author for correspondence.
Email: akezheva@list.ru
ORCID iD: 0009-0005-0518-3621
Karina A. Akezheva
4 Novy Zykovskiy Proezd, Moscow 125167
Russian FederationO. A. Aleshina
National Medical Research Center for Hematology
ORCID iD: 0000-0002-9969-8482
4 Novy Zykovskiy Proezd, Moscow 125167
Russian FederationA. N. Vasileva
National Medical Research Center for Hematology
ORCID iD: 0000-0003-4316-4833
4 Novy Zykovskiy Proezd, Moscow 125167
Russian FederationV. N. Dvirnyk
National Medical Research Center for Hematology
ORCID iD: 0000-0002-9877-0796
4 Novy Zykovskiy Proezd, Moscow 125167
Russian FederationA. A. Ershov
National Medical Research Center for Hematology
4 Novy Zykovskiy Proezd, Moscow 125167
Russian FederationT. N. Obukhova
National Medical Research Center for Hematology
ORCID iD: 0000-0003-1613-652X
4 Novy Zykovskiy Proezd, Moscow 125167
Russian FederationA. M. Kovrigin
National Medical Research Center for Hematology
ORCID iD: 0000-0002-1082-8659
4 Novy Zykovskiy Proezd, Moscow 125167
Russian FederationV. V. Troitskaya
National Medical Research Center for Hematology
ORCID iD: 0000-0002-4827-8947
4 Novy Zykovskiy Proezd, Moscow 125167
Russian FederationReferences
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