Prospects for the use of transcranial magnetic stimulation in the rehabilitation of children with brain tumors. Literature review

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Abstract

Transcranial magnetic stimulation (TMS) is a neuromodulation technology capable of targeted stimulation and inhibition of cortical areas of the brain. Currently, TMS has established itself as a method with proven effectiveness in the treatment of some psychoneurological disorders in children. In this regard, there is increasing interest in studying new options for the use of TMS in patients with acute and chronic neurological deficits. In children with brain tumors, up to 90 % of neurological disorders are determined. However, to date, there is insufficient data on the use of TMS technology in pediatric oncological neurorehabilitation.

About the authors

V. Kh. Kharbediya

Federal Children’s Rehabilitation Center “Korablik” – structural division of the Russian Children’s Clinical Hospital – branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Author for correspondence.
Email: kharbediya1992@mail.ru
ORCID iD: 0000-0001-7574-335X

Vakhtang Khvichevich Kharbediya 

4a Vysotnaya St., Podolsk, Moscow region 142114

Russian Federation

M. A. Kapranova

Federal Children’s Rehabilitation Center “Korablik” – structural division of the Russian Children’s Clinical Hospital – branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

4a Vysotnaya St., Podolsk, Moscow region 142114

Russian Federation

E. A. Salenko

Federal Children’s Rehabilitation Center “Korablik” – structural division of the Russian Children’s Clinical Hospital – branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

4a Vysotnaya St., Podolsk, Moscow region 142114

Russian Federation

A. A. Glazyrina

Federal Children’s Rehabilitation Center “Korablik” – structural division of the Russian Children’s Clinical Hospital – branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

ORCID iD: 0000-0002-2397-3484

4a Vysotnaya St., Podolsk, Moscow region 142114

Russian Federation

E. E. Petryaykina

Russian Children’s Clinical Hospital – branch of the N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

ORCID iD: 0000-0002-8520-2378

117 Leninskiy Ave., Moscow 119571 

Russian Federation

E. V. Kumirova

Morozovskaya City Children’s Clinical Hospital, Moscow Healthcare Department

ORCID iD: 0000-0001-6125-2410

1/9 4th Dobryninsky Ln., Moscow 119049 

Russian Federation

References

  1. Valiev T.T., Morozova O.V., Kovrigina A.M. et al. Diagnosis and treatment of anaplastic large cell lymphomas in children. Hematologiya i transfuzilogiya = Hematology and Transfusiology 2012;57(1):3–9. (In Russ.).
  2. Valiev T.T., Popa A.V., Levashov A.S. et al. Non­Hodgkin’s lymphoma in children: 25 years of therapy. Klinicheskaya onkogematologiya = Clinical Oncohematology 2016;9(4):420–37. (In Russ.). doi: 10.21320/2500­2139­2016­9­4­420­437
  3. Levashov A.S., Zagidullina S.R., Valiev T.T. et al. Experience of LIKE­SJMB03 protocol in treatment of children with medulloblastoma in the age group over 3 years: results of an intercenter pilot study. Sovremennaya onkologiya = Journal of Modern Oncology 2024;26(1):80–6. (In Russ.). doi: 10.26442/18151434.2024.1.202594
  4. Valiev T.T., Shervashidze M.A., Belysheva T.S. Toxicity assessment of acute lymphoblastic leukemia treatment protocol ALL IC­BFM 2002. Onkogematologiya = Oncohematology 2022;17(3):137–59. (In Russ.). doi: 10.17650/1818­8346­2022­17­3­137­159
  5. Gurieva O.D., Savelyeva M.I., Valiev T.T. Genetic basis of clinical variants of chemotherapy toxicity in children with acute lymphoblastic leukemia (literature review). Rossiyskiy zhurnal detskoy gemaologii i onkologii = Russian Journal of Pediatric Hematology and Oncology 2021;8(4):60­70. (In Russ.) doi: 10.21682/2311­1267­2021­8­4­60­70
  6. Piradov M.A., Bakulin I.S., Zabirova A.Kh. et al. Transcranial magnetic stimulation in clinical and research practice. Ed. by M.A. Piradov. Moscow: Nauchnoye izdaniye, 2024. 584 p.
  7. Klomjai W., Katz R., Lackmy­Vallee A. Basic principles of transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS). Ann Phys Rehabil Med 2015;58(4):208–13. doi: 10.1016/j.rehab.2015.05.005
  8. Lagoda D.Yu., Dobrynina L.A., Suponeva N.A. et al. Repetitive transcranial magnetic stimulation in the treatment of mild cognitive impairment due to cerebral small vessel disease. Annaly klinicheskoy i eksperimentalnoy nevrologii = Annals of Clinical and Experimental Neurology 2021;15(4):5–14. DOI: https://doi.org/10.54101/ACEN.2021.4.1
  9. Maeda F., Keenan J.P., Tormos J.M. et al. Modulation of corticospinal excitability by repetitive transcranial magnetic stimulation. Clin Neurophysiol 2000;111(5):800–5. doi: 10.1016/s1388­2457(99)00323­5
  10. Berardelli A., Inghilleri M., Rothwell J.C. et al. Facilitation of muscle evoked responses after repetitive cortical stimulation in man. Exp Brain Res 1998;122(1):79–84. doi: 10.1007/s002210050493
  11. George M.S., Lisanby S.H., Avery D. et al. Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham­controlled randomized trial. Arch Gen Psychiatry 2010;67(5):507–16. doi: 10.1001/archgenpsychiatry.2010.46
  12. George M.S., Wassermann E.M., Kimbrell T.A. et al. Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebocontrolled crossover trial. Am J Psychiatry 1997;154(12):1752–6. doi: 10.1176/ajp.154.12.1752
  13. O’Reardon J.P., Solvason H.B., Janicak P.G. et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 2007;62(11):1208–16. doi: 10.1016/j.biopsych.2007.01.018
  14. Yan J. FDA approves new option to treat major depression. Psychiatric News 2008;43(22):2–17. doi: 10.1176/pn.43.22.0002
  15. Chung S.W., Hill A.T., Rogasch N.C. et al. Use of theta­burst stimulation in changing excitability of motor cortex: a systematic review and meta­analysis. Neurosci Biobehav Rev 2016;63:43–64. doi: 10.1016/j.neubiorev.2016.01.008
  16. Hoyer E.H., Celnik P.A.. Understanding and enhancing motor recovery after stroke using transcranial magnetic stimulation. Restor Neurol Neurosci 2011;29(6):395–409. doi: 10.3233/RNN­2011­0611
  17. Hummel F.C., Cohen L.G. Non­invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke? Lancet Neurol 2006;5(8):708–12. doi: 10.1016/S1474­4422(06)70525­7
  18. He Y., Zhang Q., Ma T.T. et al. Effect of repetitive transcranial magnetic stimulation­assisted training on lower limb motor function in children with hemiplegic cerebral palsy. BMC Pediatr 2024;24(1):136. doi: 10.1186/s12887­024­04605­5
  19. Xie Y.­J., Chen Y., Tan H.­X. et al. Repetitive transcranial magnetic stimulation for lower extremity motor function in patients with stroke: a systematic review and network meta­analysis. Neural Regeneration Research 2021;16(6):1168–76. doi: 10.4103/1673­5374.300341
  20. Tarapore P.E., Picht T., Bulubas L. et al. Safety and tolerability of navigated TMS for preoperative mapping in neurosurgical patients. Clin Neurophysiol 2016;127(3):1895–900. doi: 10.1016/j.clinph.2015.11.042
  21. Kakuda W., Abo M., Kobayashi K. et al. Low­frequency rTMS combined with intensive occupational therapy for upper limb hemiparesis after brain tumour resection. Brain Injury 2010;24(12):1505–10. doi: 10.3109/02699052.2010.523040
  22. Barcia J.A., Sanz A., González­Hidalgo M. et al. rTMS stimulation to induce plastic changes at the language motor area in a patient with a left recidivant brain tumor affecting Brocaʼs area. Neurocase 2012;18(2):132–8. doi: 10.1080/13554794.2011.568500
  23. OʼNeal C.M., Stephens T.M., Briggs R.G. et al. Navigated transcranial magnetic stimulation following awake craniotomy for resection of glioma: description of two cases. Surg Neurol Int 2020;11:433. doi: 10.25259/SNI_628_2020
  24. Ille S., Kelm A., Schroeder A. et al. Navigated repetitive transcranial magnetic stimulation improves the outcome of postsurgical paresis in glioma patients – a randomized, doubleblinded trial. Brain Stimul 2021;14(4):780–7. doi: 10.1016/j.brs.2021.04.026
  25. Poologaindran A., Profyris C., Young I.M. et al. Interventional neurorehabilitation for promoting functional recovery postcraniotomy: a proof­of­concept. Sci Rep 2022;12(1):3039. doi: 10.1038/s41598­022­06766­8
  26. Rossi S., Antal A., Bestmann S. et al. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines. Clin Neurophysiol 2021;132(1):269–306. doi: 10.1016/j.clinph.2020.10.003
  27. Hausmann A., Kemmler G., Walpoth M. et al. No benefit derived from repetitive transcranial magnetic stimulation in depression: a prospective, single centre, randomised, double blind, sham controlled “add on” trial. J Neurol Neurosurg Psychiatry 2004;75(2):320–2.
  28. Siddiqi S.H., Taylor S.F., Cooke D. et al. Distinct symptom­specific treatment targets for circuit­based neuromodulation. Am J Psychiatry 2020;177(5):435–46. doi: 10.1176/appi.ajp.2019.19090915
  29. Rosen A.C., Bhat J.V., Cardenas V.A. et al. Targeting location relates to treatment response in active but not sham rTMS stimulation. Brain Stimul 2021;14(3):703–9. doi: 10.1016/j.brs.2021.04.010
  30. Dadario N.B., Brahimaj B., Yeung J., Sughrue M.E. Reducing the cognitive footprint of brain tumor surgery. Front Neurol 2021;12:711646. doi: 10.3389/fneur.2021.711646
  31. Moreno­Ortega M., Kangarlu A., Lee S. et al. Parcel­guided rTMS for depression. Translational Psychiatry 2020;10(1):283 doi: 10.1038/s41398­020­00970­8
  32. Einstein E.H., Dadario N.B., Khilji H. et al. Transcranial magnetic stimulation for post­operative neurorehabilitation in neurooncology: a review of the literature and future directions. J Neurooncol 2022;157(3):435–43. doi: 10.1007/s11060­022­03987­9

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