Epidemiological and clinical features of multiple myeloma in Russia: results of a multicenter prospective study

M. V. Solovev; Соловьев Максим Валерьевич; L. P. Mendeleeva; Менделеева Л. П.; M. V. Soloveva; Соловьева М. В.; O. S. Samoylova; Самойлова О. С.; I. L. Davydkin; Давыдкин И. Л.; T. A. Gritsenko; Гриценко Т. А.; K. D. Kaplanov; Капланов К. Д.; T. S. Kaporskaya; Капорская Т. С.; T. V. Shelehova; Шелехова Т. В.; E. M. Volodicheva; Володичева Е. М.; T. I. Pospelova; Поспелова Т. И.; N. V. Skvortsova; Скворцова Н. В.; S. S. Belyaeva; Беляева С. С.; E. O. Gribanova; Грибанова Е. О.; I. M. Nakastoev; Накастоев И. М.; I. G. Rekhtina; Рехтина И. Г.; N. N. Rachkova; Рачкова Н. Н.; M. Y.  Kiseleva; Киселева М. Я.; A. A. Amdiev; Амдиев А. А.; T. S. Konstantinova; Константинова Т. С.; G. R. Gaynullina; Гайнуллина Г. Р.; G. B. Kuchma; Кучма Г. Б.; S. A. Lebedenko; Лебеденко С. А.; M. T. Savinova; Савинова М. Т.; S. M. Osyunikhina; Осюнихина С. М.; E. V. Martynova; Мартынова Е. В.; V. I. Bakhtina; Бахтина В. И.; S. N. Menshakova; Меньшакова С. Н.; E. A. Filatova; Филатова Е. А.; T. I. Ksenzova; Ксензова Т. И.; I. I. Shakirov; Шакиров И. И.; O. E. Ochirova; Очирова О. Е.; A. N. Alekseeva; Алексеева А. Н.; E. V. Voronova; Воронова Е. В.; V. Z. Molostova; Молостова В. З.; N. N. Glonina; Глонина Н. Н.; I. S. Verkhoglyad; Верхогляд И. С.; M. V. Frolova; Фролова М. В.; O. A. Dianova; Дианова О. А.; M. V. Kosinova; Косинова М. В.; T. I. Olkhovik; Ольховик Т. И.; M. A. Mikhalev; Михалев М. А.; T. M. Sycheva; Сычева Т. М.; Z. A. Davydova; Давыдова Ж. А.; I. A. Novokreshchenova; Новокрещенова И. А.; Y. A. Dunaev; Дунаев Ю. А.; T. V. Chagorova; Чагорова Т. В.; M. A. Kunst; Кунст М. А.; E. N. Zotina; Зотина Е. Н.; M. N. Kozmina; Козьмина М. Н.; V. A. Lapin; Лапин В. А.; A. S. Gvozdareva; Гвоздарева А. С.; E. G. Kirillova; Кириллова Е. Г.; Y. D. Tsinchenko; Цинченко Я. Д.; N. D. Baygishieva; Байгишиева Н. Д.; E. V. Tarasenko; Тарасенко Е. В.; E. V. Patrakova; Патракова Е. В.; E. A. Borisenkova; Борисенкова Е. А.; E. E. Zinina; Зинина Е. Е.; N. B. Popova; Попова Н. Б.; N. I. Stepanova; Степанова Н. И.; O. L. Panteleeva; Пантелеева О. Л.; A. A. Shutylev; Шутылев А. А.; N. B. Esefeva; Есефьева Н. Б.; I. S. Sokolova; Соколова И. С.

doi:10.17650/2782-3202-2026-6-1-62-80

Epidemiological and clinical features of multiple myeloma in Russia: results of a multicenter prospective study

Authors: Solovev M.V.¹, Mendeleeva L.P.¹, Soloveva M.V.¹, Samoylova O.S.², Davydkin I.L.³, Gritsenko T.A.³, Kaplanov K.D.⁴, Kaporskaya T.S.⁵, Shelehova T.V.⁶, Volodicheva E.M.⁷, Pospelova T.I.⁸, Skvortsova N.V.⁸, Belyaeva S.S.⁹, Gribanova E.O.¹, Nakastoev I.M.¹, Rekhtina I.G.¹, Rachkova N.N.¹⁰, Kiseleva M.Y.¹¹, Amdiev A.A.¹¹, Konstantinova T.S.¹², Gaynullina G.R.¹³, Kuchma G.B.¹³^,14, Lebedenko S.A.¹³, Savinova M.T.¹⁵, Osyunikhina S.M.¹⁶, Martynova E.V.¹⁷, Bakhtina V.I.¹⁷, Menshakova S.N.¹⁸, Filatova E.A.¹⁹, Ksenzova T.I.²⁰, Shakirov I.I.²⁰, Ochirova O.E.²¹, Alekseeva A.N.²¹, Voronova E.V.²², Molostova V.Z.²³, Glonina N.N.²³, Verkhoglyad I.S.²³, Frolova M.V.²⁴, Dianova O.A.²⁵, Kosinova M.V.²⁶, Olkhovik T.I.²⁷, Mikhalev M.A.²⁷, Sycheva T.M.²⁸, Davydova Z.A.²⁹, Novokreshchenova I.A.²⁹, Dunaev Y.A.³⁰, Chagorova T.V.³¹, Kunst M.A.³², Zotina E.N.³³, Kozmina M.N.³⁴, Lapin V.A.³⁵, Gvozdareva A.S.³⁵, Kirillova E.G.³⁶, Tsinchenko Y.D.³⁶, Baygishieva N.D.³⁷, Tarasenko E.V.³⁸, Patrakova E.V.³⁹, Borisenkova E.A.⁴⁰, Zinina E.E.⁴¹, Popova N.B.⁴¹, Stepanova N.I.⁴², Panteleeva O.L.⁴³, Shutylev A.A.⁴⁴, Esefeva N.B.⁴⁵, Sokolova I.S.⁴⁶
Affiliations:
1. National Medical Research Center for Hematology, Ministry of Health of Russia
2. Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko
3. Samara State Medical University, Ministry of Health of Russia
4. Botkin Hospital, Moscow Healthcare Department
5. Irkutsk Regional Clinical Hospital, holder of the Order “Znak Pocheta”
6. Saratov State Medical University named after V.I. Razumovsky, Ministry of Health of Russia
7. SSMC REGION No. 2
8. City Clinical Hospital No. 2, Novosibirsk
9. Belgorod Regional Clinical Hospital of St. Joasaph
10. Bryansk Regional Hospital No. 1
11. Republican Clinical Hospital named after N.A. Semashko, Simferopol
12. Sverdlovsk Regional Clinical Hospital No. 1
13. Orenburg Regional Clinical Hospital named after V.I. Voynov
14. Orenburg State Medical University
15. City Clinical Hospital No. 16, Kazan
16. Republican Clinical Hospital No. 4, Saransk
17. Krasnoyarsk Regional Clinical Hospital
18. Regional Clinical Hospital, Tver
19. Amur Regional Clinical Hospital
20. Regional Clinical Hospital No. 1, Tyumen
21. Republican Clinical Hospital named after N.A. Semashko, Ulan-Ude
22. Tambov Regional Clinical Hospital named after V.D. Babenko
23. Regional Clinical Hospital named after Prof. S.I. Sergeev
24. Vologda Regional Clinical Hospital
25. Kuzbass Clinical Oncology Dispensary named after M.S. Rappoport
26. Kuzbass Clinical Hospital named after S.V. Belyaev
27. Krasnoyarsk City Clinical Hospital No. 7
28. Aleksandro-Mariinskiy Regional Clinical Hospital
29. Branch Hospital at Smolensk Station of Russian Railways
30. Arkhangelsk Regional Clinical Hospital
31. Regional Oncology Clinical Dispensary, Penza
32. Republican Clinical Hospital, Kazan
33. I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenovskiy University)
34. Polyclinic No. 2, Orel
35. Regional Clinical Hospital, Yaroslavl
36. Regional Clinical Hospital, Omsk
37. Republican Clinical Hospital named after A.V. Vishnevskiy
38. City Hospital No. 1 named after N.I. Pirogov
39. Vologda Regional Clinical Hospital No. 2
40. Kaluga Regional Clinical Hospital
41. Surgut District Clinical Hospital
42. Orsk City Hospital
43. Regional Clinical Hospital, Vladimir
44. Perm Regional Clinical Hospital, holder of the Order “Znak Pocheta”
45. Ulyanovsk Regional Clinical Hospital
46. Komi Republican Oncology Dispensary
Issue: Vol 6, No 1 (2026)
Pages: 62-80
Section: THEORETICAL ASPECTS AND BASIC RESEARCH IN ONCOLOGY IN THE CURRENT AGE
Published: 08.04.2026
URL: https://mdonco.abvpress.ru/jour/article/view/224
DOI: https://doi.org/10.17650/2782-3202-2026-6-1-62-80
ID: 224

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Abstract

Background. Epidemiological studies aggregating data on newly diagnosed multiple myeloma (MM) from real-world clinical practice allow to analyze various clinical and laboratory parameters characterizing general trends in MM diagnosis, treatment outcomes, and life expectancy.

Aim. To determine overall survival rates in patients with newly diagnosed MM and to examine factors influencing survival in a population-based study.

Materials and methods. A total of 3,184 patients with a newly diagnosed MM from 40 regions of Russia were enrolled in a multicenter prospective study from January 2, 2015, to October 4, 2018. Complete registration of newly diagnosed cases was conducted at each of the 44 participating centers. Information on clinical and laboratory parameters, antitumor therapy regimens administered to patients, including autologous transplantation, was analyzed.

Results. The median age of MM patients in Russia was 63 years. It was shown that 39 % of the patients belonged to the older age group 66–90 years, and the percentage of patients under 55 years was 22 %. Only 9 % of patients underwent bone marrow cytogenetic testing. The proportion of patients with kidney damage was 26 %, while 5 % of patients were dialysis dependent. It was shown that 78 % of patients were diagnosed with stage 3 according to Durie–Salmon system, and in 52 % of cases, stage III according to International Staging System was diagnosed. Induction therapy included the use of bortezomib in 94 % of cases, the VCD regimen (bortezomib + dexamethasone + cyclophosphamide) was mainly used, lenalidomide was prescribed extremely rarely – in 1 % of cases. The proportion of patients under 65 years of age who received at least one autologous hematopoietic stem cell transplant was only 18 %. With autologous hematopoietic stem cell transplantation, the median overall survival was 107 months, and in the case of maintenance therapy with lenalidomide, it increased to 129 months. Five-year overall survival of the entire group of patients was 40 %. In a multivariate analysis, independent predictors of worse overall survival were Durie–Salmon stage III, substage B, profound anemia (hemoglobin ≤80 g/L), albumin ≤30 g/L, and hypercalcemia (≥3 mmol/L).

Conclusion. This multicenter prospective study of the epidemiological and clinical parameters of newly diagnosed multiple myeloma is unique in Russia in terms of coverage and follow-up duration (over 10 years). Analysis of treatment data for newly diagnosed multiple myeloma identified key issues in diagnosis and treatment.

Keywords

multiple myeloma, epidemiological study, overall survival, autologous hematopoietic cell transplantation, induction therapy, real-world clinical practice

About the authors

M. V. Solovev

National Medical Research Center for Hematology, Ministry of Health of Russia

Author for correspondence.
Email: maxsolovej@mail.ru
ORCID iD: 0000-0002-7944-6202
Russian Federation, 4 Novyy Zykovskiy Proezd, Moscow 125167

L. P. Mendeleeva

National Medical Research Center for Hematology, Ministry of Health of Russia

Email: maxsolovej@mail.ru
ORCID iD: 0000-0002-4966-8146
Russian Federation, 4 Novyy Zykovskiy Proezd, Moscow 125167

M. V. Soloveva

National Medical Research Center for Hematology, Ministry of Health of Russia

Email: maxsolovej@mail.ru
ORCID iD: 0000-0003-4142-171X
Russian Federation, 4 Novyy Zykovskiy Proezd, Moscow 125167

O. S. Samoylova

Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko

Email: maxsolovej@mail.ru
Russian Federation, 190 Rodionova St., Nizhny Novgorod 603093

I. L. Davydkin

Samara State Medical University, Ministry of Health of Russia

Email: maxsolovej@mail.ru
ORCID iD: 0000-0002-4318-4247
Russian Federation, 89 Chapaevskaya St., Samara 443099

T. A. Gritsenko

Samara State Medical University, Ministry of Health of Russia

Email: maxsolovej@mail.ru
Russian Federation, 89 Chapaevskaya St., Samara 443099

K. D. Kaplanov

Botkin Hospital, Moscow Healthcare Department

Email: maxsolovej@mail.ru
ORCID iD: 0000-0001-6574-0518

during the data collection period, he worked at the Volgograd Regional Clinical Oncology Dispensary, 78 Zemlyachki St., Volgograd 400138

Russian Federation, 5 2nd Botkinskiy Proezd, Moscow 125284

T. S. Kaporskaya

Irkutsk Regional Clinical Hospital, holder of the Order “Znak Pocheta”

Email: maxsolovej@mail.ru
Russian Federation, 100 Yubileyny, Irkutsk 664049

T. V. Shelehova

Saratov State Medical University named after V.I. Razumovsky, Ministry of Health of Russia

Email: maxsolovej@mail.ru
Russian Federation, 112 Bolshaya Kazachya St., Saratov 410012

E. M. Volodicheva

SSMC REGION No. 2

Email: maxsolovej@mail.ru
ORCID iD: 0000-0002-3011-9729

during the data collection period, she worked at the Tula Regional Clinical Hospital, 58 F. Engels St., Tula 300035

Russian Federation, 1 Zavodskoy Proezd, Ryazan 390013

T. I. Pospelova

City Clinical Hospital No. 2, Novosibirsk

Email: maxsolovej@mail.ru
ORCID iD: 0000-0002-1261-5470
Russian Federation, 21 Polzunova St., Novosibirsk 630051

N. V. Skvortsova

City Clinical Hospital No. 2, Novosibirsk

Email: maxsolovej@mail.ru
ORCID iD: 0000-0001-6938-3802
Russian Federation, 21 Polzunova St., Novosibirsk 630051

S. S. Belyaeva

Belgorod Regional Clinical Hospital of St. Joasaph

Email: maxsolovej@mail.ru
Russian Federation, 8/9 Nekrasov St., Belgorod 308007,

E. O. Gribanova

National Medical Research Center for Hematology, Ministry of Health of Russia

Email: maxsolovej@mail.ru
Russian Federation, 4 Novyy Zykovskiy Proezd, Moscow 125167

I. M. Nakastoev

National Medical Research Center for Hematology, Ministry of Health of Russia

Email: maxsolovej@mail.ru
Russian Federation, 4 Novyy Zykovskiy Proezd, Moscow 125167

I. G. Rekhtina

National Medical Research Center for Hematology, Ministry of Health of Russia

Email: maxsolovej@mail.ru
Russian Federation, 4 Novyy Zykovskiy Proezd, Moscow 125167

N. N. Rachkova

Bryansk Regional Hospital No. 1

Email: maxsolovej@mail.ru
Russian Federation, 86 Stanke Dimitrova Prospekt, Bryansk 241050

M. Y. Kiseleva

Republican Clinical Hospital named after N.A. Semashko, Simferopol

Email: maxsolovej@mail.ru
Russian Federation, 69 Kyiv St., Simferopol 295017

A. A. Amdiev

Republican Clinical Hospital named after N.A. Semashko, Simferopol

Email: maxsolovej@mail.ru
Russian Federation, 69 Kyiv St., Simferopol 295017

T. S. Konstantinova

Sverdlovsk Regional Clinical Hospital No. 1

Email: maxsolovej@mail.ru
Russian Federation, 185 Volgogradskaya St., Ekaterinburg 620102,

G. R. Gaynullina

Orenburg Regional Clinical Hospital named after V.I. Voynov

Email: maxsolovej@mail.ru
Russian Federation, 23 Aksakova St., Orenburg 460018,

G. B. Kuchma

Orenburg Regional Clinical Hospital named after V.I. Voynov; Orenburg State Medical University

Email: maxsolovej@mail.ru
ORCID iD: 0000-0002-2063-8859
Russian Federation, 23 Aksakova St., Orenburg 460018; 6 Sovetskaya St., Orenburg 460014

S. A. Lebedenko

Orenburg Regional Clinical Hospital named after V.I. Voynov

Email: maxsolovej@mail.ru
Russian Federation, 23 Aksakova St., Orenburg 460018

M. T. Savinova

City Clinical Hospital No. 16, Kazan

Email: maxsolovej@mail.ru
Russian Federation, 121 Gagarina St., Kazan 420039

S. M. Osyunikhina

Republican Clinical Hospital No. 4, Saransk

Email: maxsolovej@mail.ru
Russian Federation, 32 Ulyanova St., Saransk 430032

E. V. Martynova

Krasnoyarsk Regional Clinical Hospital

Email: maxsolovej@mail.ru
ORCID iD: 0000-0002-2504-7265
Russian Federation, 3A Partizana Zheleznyaka St., Krasnoyarsk 660022

V. I. Bakhtina

Krasnoyarsk Regional Clinical Hospital

Email: maxsolovej@mail.ru
Russian Federation, 3A Partizana Zheleznyaka St., Krasnoyarsk 660022

S. N. Menshakova

Regional Clinical Hospital, Tver

Email: maxsolovej@mail.ru
Russian Federation, 105 Peterburgskoe Shosse, Tver 170036

E. A. Filatova

Amur Regional Clinical Hospital

Email: maxsolovej@mail.ru
Russian Federation, 26 Voronkova St., Blagoveshchensk 675028

T. I. Ksenzova

Regional Clinical Hospital No. 1, Tyumen

Email: maxsolovej@mail.ru
Russian Federation, 55 Kotovskogo St., Tyumen 625023

I. I. Shakirov

Regional Clinical Hospital No. 1, Tyumen

Email: maxsolovej@mail.ru
Russian Federation, 55 Kotovskogo St., Tyumen 625023

O. E. Ochirova

Republican Clinical Hospital named after N.A. Semashko, Ulan-Ude

Email: maxsolovej@mail.ru
ORCID iD: 0000-0002-0145-3226
Russian Federation, 12 Pavlova St., Ulan-Ude 670031

A. N. Alekseeva

Republican Clinical Hospital named after N.A. Semashko, Ulan-Ude

Email: maxsolovej@mail.ru
Russian Federation, 12 Pavlova St., Ulan-Ude 670031

E. V. Voronova

Tambov Regional Clinical Hospital named after V.D. Babenko

Email: maxsolovej@mail.ru
Russian Federation, 29 Moskovskaya St., Tambov 392000

V. Z. Molostova

Regional Clinical Hospital named after Prof. S.I. Sergeev

Email: maxsolovej@mail.ru
Russian Federation, 9 Krasnodarskaya St., Khabarovsk 680009

N. N. Glonina

Regional Clinical Hospital named after Prof. S.I. Sergeev

Email: maxsolovej@mail.ru
Russian Federation, 9 Krasnodarskaya St., Khabarovsk 680009

I. S. Verkhoglyad

Regional Clinical Hospital named after Prof. S.I. Sergeev

Email: maxsolovej@mail.ru
Russian Federation, 9 Krasnodarskaya St., Khabarovsk 680009

M. V. Frolova

Vologda Regional Clinical Hospital

Email: maxsolovej@mail.ru
Russian Federation, 17 Lechebnaya St., Vologda 160002

O. A. Dianova

Kuzbass Clinical Oncology Dispensary named after M.S. Rappoport

Email: maxsolovej@mail.ru

during the data collection period, she worked in Kuzbass Clinical Hospital named after S.V. Belyaev, 22 Oktyabrskiy Prospekt, Kemerovo 650066

Russian Federation, 35 Volgogradskaya St., Kemerovo 650036

M. V. Kosinova

Kuzbass Clinical Hospital named after S.V. Belyaev

Email: maxsolovej@mail.ru
Russian Federation, 22 Oktyabrskiy Prospekt, Kemerovo 650066

T. I. Olkhovik

Krasnoyarsk City Clinical Hospital No. 7

Email: maxsolovej@mail.ru
Russian Federation, 4 Akademika Pavlova St., Krasnoyarsk 660003

M. A. Mikhalev

Krasnoyarsk City Clinical Hospital No. 7

Email: maxsolovej@mail.ru
Russian Federation, 4 Akademika Pavlova St., Krasnoyarsk 660003

T. M. Sycheva

Aleksandro-Mariinskiy Regional Clinical Hospital

Email: maxsolovej@mail.ru
Russian Federation, 2 Tatishchev St., Astrakhan 414056,

Z. A. Davydova

Branch Hospital at Smolensk Station of Russian Railways

Email: maxsolovej@mail.ru
Russian Federation, 15 1st Krasnoflotskiy Pereulok, Smolensk 214025

I. A. Novokreshchenova

Branch Hospital at Smolensk Station of Russian Railways

Email: maxsolovej@mail.ru
Russian Federation, 15 1st Krasnoflotskiy Pereulok, Smolensk 214025

Y. A. Dunaev

Arkhangelsk Regional Clinical Hospital

Email: maxsolovej@mail.ru
Russian Federation, 292 Lomonosova Prospekt, Arkhangelsk 163045

T. V. Chagorova

Regional Oncology Clinical Dispensary, Penza

Email: maxsolovej@mail.ru
Russian Federation, 37A Stroiteley Prospekt, Penza 440071

M. A. Kunst

Republican Clinical Hospital, Kazan

Email: maxsolovej@mail.ru
Russian Federation, 138 Orenburgskiy Trakt, Kazan 420064

E. N. Zotina

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenovskiy University)

Email: maxsolovej@mail.ru

during the data collection period, she worked at the Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency, 72 Krasnoarmeyskaya St., Kirov 610027

Russian Federation, Build. 2, 8 Trubetskaya St., Moscow 119048

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