Neoadjuvant immunotherapy in treatment of oligometastatic locally advanced colon cancer. Clinical case

A. O. Rasulov; Расулов А. О.; J. M. Madyarov; Мадьяров Ж. М.; A. E. Kulikov; Куликов А. Э.; Z. R. Rasulov; Расулов З. Р.; L. A. Shestakova; Шестакова Л. А.; D. A. Chekini; Чекини Д. А.; E. K. Ibragimov; Ибрагимов Э. К.; E. N. Puchkova; Пучкова Е. Н.; Yu. E. Lvova; Львова Ю. Э.; R. A. Rasulov; Расулов Р. А.

doi:10.17650/2782-3202-2022-2-3-21-27

Neoadjuvant immunotherapy in treatment of oligometastatic locally advanced colon cancer. Clinical case

Authors: Rasulov A.O.¹, Madyarov J.M.¹, Kulikov A.E.¹, Rasulov Z.R.¹, Shestakova L.A.¹, Chekini D.A.¹, Ibragimov E.K.¹, Puchkova E.N.¹, Lvova Y.E.², Rasulov R.A.³
Affiliations:
1. Clinical Hospital “Lapino” of the “Mother and Child” Group of companies
2. Centrosoyuz Hospital of the Russian Federation
3. I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Issue: Vol 2, No 3 (2022)
Pages: 21-27
Section: RARE NEOPLASMS: COMPLEX CLINICAL SITUATIONS AND SELECTION OF TREATMENT TACTICS
Published: 13.10.2022
URL: https://mdonco.abvpress.ru/jour/article/view/41
DOI: https://doi.org/10.17650/2782-3202-2022-2-3-21-27
ID: 41

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Abstract

Immunotherapy has improved the results of treatment of patients with metastatic colorectal cancer. According to literature, the most cancericidal effect revealed in a microsatellite instability high (MSI-H) tumors. In our case, PD-1/PD-L1/PD-L2 inhibitors (nivolumab) treatment for locally advanced MSI-H colon carcinoma with liver metastasis in 44-year-old patient resulted in tumor regression, so that R0 surgical procedure became possible. Computed tomography scan and pathology report showed complete response, in primary and metastatic tumors. As a result, this allowed to improve the quality of patient’s life.