CDK4/6 inhibitors in combination with hormone therapy in clinical practice. Clinical case

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Abstract

Currently, use of CDK4/6 inhibitors in combination with hormone therapy is approved for treatment of patients with advanced or metastatic breast cancer positive for estrogen and progesterone receptors and negative for human epidermal growth factor receptor 2 (HER2). In this clinical observation, analysis of the effectiveness of treatment of a patient with metastatic breast cancer of luminal A subtype is performed. The 1st line combination therapy was CDK4/6 inhibitors (ribociclib) and hormone therapy with aromatase inhibitors (letrozole) and analogues of gonadotropin-releasing hormone (goserelin) with concurrent bone-modifying denosumab therapy. Effectiveness of antitumor drug therapy administered for 7 months, and toxicity of the regimen were evaluated. Effectiveness of the selected combination treatment regimen was demonstrated and confirmed by clinical data, as well as results of laboratory and instrumental examinations. Adverse effects were controlled and managed with symptomatic therapy which allows to continue treatment using previously selected tactics.

About the authors

D. A. Chekini

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

Author for correspondence.
Email: d.chekini@mcclinics.ru

Jennet A. Chekini

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

 

Russian Federation

P. A. Zeynalova

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies;
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

ORCID iD: 0000-0003-1564-424X

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081,

Bld. 2, 8 Trubetskaya St., Moscow 119991

Russian Federation

E. K. Ibragimov

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0002-8361-6200

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

 

Russian Federation

A. Yu. Kolesnik

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

 

Russian Federation

A. A. Fedenko

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0003-4927-5585

111 1st Uspenskoe Shosse, Lapino, Moscow region 143081

 

Russian Federation

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