Noninvasive colorectal cancer screening techniques: literature review

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Abstract

   Fecal DNA testing is a noninvasive method recommended by professional medical societies for colorectal cancer screening in individuals with intermediate risk of the disease. Adenamatous and serrated lesions, as well as cancer, lead to exfoliation of cells containing neoplastic altered DNA which, in turn, can be detected with sensitive testing methods aimed at specific genetic and epigenetic biomarkers. Mt-sDNA test approved by the United States Food and Drug Administration in 2014 showed sensitivity of 92 % for detection of colorectal cancer which is much higher than sensitivity of fecal immunochemical test (74 %).

About the authors

V. V. Vereshchak

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

Author for correspondence.
Email: vvvereshchak@yandex.ru
ORCID iD: 0000-0002-6850-6919

Valeria Vadimovna Vereshchak

143081

111 1st Uspenskoe Shosse

Moscow region

Lapino

Russian Federation

I. N. Iurichev

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0002-1345-041X

143081

111 1st Uspenskoe Shosse

Moscow region

Lapino

Russian Federation

A. O. Rasulov

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0002-5565-615X

143081

111 1st Uspenskoe Shosse

Moscow region

Lapino

Russian Federation

J. M. Madyarov

Clinical Hospital “Lapino” of the “Mother and Child” Group of companies

ORCID iD: 0000-0001-9992-3822

143081

111 1st Uspenskoe Shosse

Moscow region

Lapino

Russian Federation

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