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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">MD-Onco</journal-id><journal-title-group><journal-title xml:lang="en">MD-Onco</journal-title><trans-title-group xml:lang="ru"><trans-title>MD-Onco</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2782-3202</issn><issn publication-format="electronic">2782-6171</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">202</article-id><article-id pub-id-type="doi">10.17650/2782-3202-2025-5-3-94-102</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>THEORETICAL AND DISCUSSIBLE ASPECTS IN ONCOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ТЕОРЕТИЧЕСКИЕ И ДИСКУТАБЕЛЬНЫЕ АСПЕКТЫ В ОНКОЛОГИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Dendritic cell vaccines for lung cancer: current status and development prospects. Literature review</article-title><trans-title-group xml:lang="ru"><trans-title>Дендритно-клеточные вакцины при раке легкого: современное состояние и перспективы развития. Обзор литературы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9616-8996</contrib-id><name-alternatives><name xml:lang="en"><surname>Sheiko</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Шейко</surname><given-names>Е. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>63 14th Line St., Rostov-on-Don 344038</p></bio><bio xml:lang="ru"><p>344038 Ростов-на-Дону, 14-я линия, 63</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3618-6890</contrib-id><name-alternatives><name xml:lang="en"><surname>Frantsiyants</surname><given-names>E. M.</given-names></name><name xml:lang="ru"><surname>Франциянц</surname><given-names>Е. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>63 14th Line St., Rostov-on-Don 344038</p></bio><bio xml:lang="ru"><p>344038 Ростов-на-Дону, 14-я линия, 63</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2302-8271</contrib-id><name-alternatives><name xml:lang="en"><surname>Bandovkina</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Бандовкина</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>63 14th Line St., Rostov-on-Don 344038</p></bio><bio xml:lang="ru"><p>344038 Ростов-на-Дону, 14-я линия, 63</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4318-7587</contrib-id><name-alternatives><name xml:lang="en"><surname>Surikova</surname><given-names>E. I.</given-names></name><name xml:lang="ru"><surname>Сурикова</surname><given-names>Е. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>63 14th Line St., Rostov-on-Don 344038</p></bio><bio xml:lang="ru"><p>344038 Ростов-на-Дону, 14-я линия, 63</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2943-7655</contrib-id><name-alternatives><name xml:lang="en"><surname>Shikhlyarova</surname><given-names>A. I.</given-names></name><name xml:lang="ru"><surname>Шихлярова</surname><given-names>А. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>63 14th Line St., Rostov-on-Don 344038</p></bio><bio xml:lang="ru"><p>344038 Ростов-на-Дону, 14-я линия, 63</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3972-2452</contrib-id><name-alternatives><name xml:lang="en"><surname>Kaplieva</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Каплиева</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>63 14th Line St., Rostov-on-Don 344038</p></bio><bio xml:lang="ru"><p>344038 Ростов-на-Дону, 14-я линия, 63</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0068-0881</contrib-id><name-alternatives><name xml:lang="en"><surname>Ushakova</surname><given-names>N. D.</given-names></name><name xml:lang="ru"><surname>Ушакова</surname><given-names>Н. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>63 14th Line St., Rostov-on-Don 344038</p></bio><bio xml:lang="ru"><p>344038 Ростов-на-Дону, 14-я линия, 63</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4558-5896</contrib-id><name-alternatives><name xml:lang="en"><surname>Filippova</surname><given-names>S. Yu.</given-names></name><name xml:lang="ru"><surname>Филиппова</surname><given-names>С. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>63 14th Line St., Rostov-on-Don 344038</p></bio><bio xml:lang="ru"><p>344038 Ростов-на-Дону, 14-я линия, 63</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7902-7278</contrib-id><name-alternatives><name xml:lang="en"><surname>Mezhevova</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Межевова</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>63 14th Line St., Rostov-on-Don 344038</p></bio><bio xml:lang="ru"><p>344038 Ростов-на-Дону, 14-я линия, 63</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0640-2994</contrib-id><name-alternatives><name xml:lang="en"><surname>Kharagezov</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Харагезов</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>63 14th Line St., Rostov-on-Don 344038</p></bio><bio xml:lang="ru"><p>344038 Ростов-на-Дону, 14-я линия, 63</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">National Medical Research Center of Oncology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-09-21" publication-format="electronic"><day>21</day><month>09</month><year>2025</year></pub-date><volume>5</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>94</fpage><lpage>102</lpage><history><date date-type="received" iso-8601-date="2025-09-21"><day>21</day><month>09</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-09-21"><day>21</day><month>09</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, ABV-Press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, АБВ-пресс</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">ABV-Press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://mdonco.abvpress.ru/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://mdonco.abvpress.ru/jour/article/view/202">https://mdonco.abvpress.ru/jour/article/view/202</self-uri><abstract xml:lang="en"><p>This paper presents a literature review on the use of dendritic cell vaccines for lung cancer, prepared based on the analysis of sources from domestic and foreign literature presented in electronic databases of scientific medical literature PabMed, eLIBRARY.RU. The analysis included publications characterizing the current capabilities of laboratory, instrumental and molecular genetic methods for obtaining and using dendritic cell vaccines for lung cancer.The aim of the work – to highlight the results of international and domestic studies on the production, screening and use of dendritic cell vaccines, as well as immunotherapy strategies for lung cancer.</p></abstract><trans-abstract xml:lang="ru"><p>Представлен обзор литературы, посвященной использованию дендритно-клеточных вакцин при раке легкого. Обзор подготовлен по результатам анализа отечественных и зарубежных работ, представленных в электронных базах данных научной медицинской литературы PubMed, eLIBRARY. В анализ включали публикации, характеризующие современные возможности лабораторных, инструментальных и молекулярно-генетических методов получения и использования дендритно-клеточных вакцин при раке легкого.Цель работы – осветить результаты международных и отечественных исследований получения, скрининга использования дендритно-клеточных вакцин, а также стратегии иммунотерапии при раке легкого.</p></trans-abstract><kwd-group xml:lang="en"><kwd>lung cancer</kwd><kwd>dendritic cell</kwd><kwd>dendritic cell vaccine</kwd><kwd>immunotherapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак легкого</kwd><kwd>дендритная клетка</kwd><kwd>дендритно-клеточная вакцина</kwd><kwd>иммунотерапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Bray F., Ferlay J., Soerjomataram I. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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