<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">MD-Onco</journal-id><journal-title-group><journal-title xml:lang="en">MD-Onco</journal-title><trans-title-group xml:lang="ru"><trans-title>MD-Onco</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2782-3202</issn><issn publication-format="electronic">2782-6171</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">23</article-id><article-id pub-id-type="doi">10.17650/2782-3202-2022-2-1-19-27</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>RARE NEOPLASMS AND COMPLEX CLINICAL SITUATIONS: DIFFICULTIES IN DIAGNOSIS AND SELECTION OF TREATMENT TACTICS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>РЕДКИЕ НОВООБРАЗОВАНИЯ И СЛОЖНЫЕ КЛИНИЧЕСКИЕ СИТУАЦИИ: ТРУДНОСТИ ДИАГНОСТИКИ И ВЫБОР ТАКТИКИ ЛЕЧЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Clinical observation of cervical esophageal cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Клиническое наблюдение рака шейного отдела пищевода</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0918-3857</contrib-id><name-alternatives><name xml:lang="en"><surname>Mudunov</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Мудунов</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>43081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1794-7247</contrib-id><name-alternatives><name xml:lang="en"><surname>Batsev</surname><given-names>A. F.</given-names></name><name xml:lang="ru"><surname>Бацев</surname><given-names>А. Ф.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>43081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><email>batsevhph@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Maryenko</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Марьенко</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>43081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shogenov</surname><given-names>M. S.</given-names></name><name xml:lang="ru"><surname>Шогенов</surname><given-names>М. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>43081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Clinical Hospital “Lapino” of the “Mother and Child” Group of companies</institution></aff><aff><institution xml:lang="ru">Клинический госпиталь «Лапино» группы компаний «Мать и дитя»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-03-07" publication-format="electronic"><day>07</day><month>03</month><year>2022</year></pub-date><volume>2</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>19</fpage><lpage>27</lpage><history><date date-type="received" iso-8601-date="2022-03-05"><day>05</day><month>03</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-03-05"><day>05</day><month>03</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, ABV-Press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, АБВ-пресс</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">ABV-Press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://mdonco.abvpress.ru/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://mdonco.abvpress.ru/jour/article/view/23">https://mdonco.abvpress.ru/jour/article/view/23</self-uri><abstract xml:lang="en"><p>Esophageal cancer is one of the hardest to treat malignant cancers. Patient prognosis remains unsatisfactory despite considerable progress in surgical, radiation, and drug treatments. Surgery remains the main form of treatment for this pathology as it is the only radical treatment method. The objective is to evaluate short-term treatment results for cancer of the cervical esophagus and laryngopharynx after large-scale resection with reconstruction and plastic surgery stage. A clinical case of locally advanced squamous cell carcinoma of the mucosa of the cervical esophagus is presented. Use of free radial fasciocutaneous flap for reconstruction of the cervical esophagus with preservation of the pharynx is described. Problems of diagnosis and surgical treatment of this pathology from the point of view of our clinic’s experience are considered. We show that radial forearm flap can be used for reconstruction of the pharynx and cervical esophagus during circular resections.</p></abstract><trans-abstract xml:lang="ru"><p>Рак пищевода является одним из самых трудноизлечимых злокачественных новообразований. Прогноз пациентов остается неудовлетворительным, несмотря на значительный прогресс в области хирургического, лучевого и лекарственного лечения. Тем не менее хирургический метод остается ведущим в лечении данной патологии как единственный метод радикального лечения. Цель работы – оценка непосредственных результатов лечения рака шейного отдела пищевода и гортаноглотки после обширной резекции с реконструктивно-пластическим этапом. Представлено клиническое наблюдение местно-распространенного плоскоклеточного рака слизистой оболочки шейного отдела пищевода. Продемонстрирован опыт использования свободного лучевого кожно-фасциального лоскута для реконструкции шейного отдела пищевода с сохранением гортани. Освещены вопросы диагностики и хирургического лечения данной патологии на основе опыта клиники. Показано, что лучевой лоскут предплечья может быть использован для реконструкции глотки и шейного отдела пищевода при циркулярных резекциях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>locally advanced cervical esophageal cancer</kwd><kwd>squamous cell carcinoma of the esophagus</kwd><kwd>surgical treatment of the esophagus</kwd><kwd>resection of the cervical esophagus</kwd><kwd>plastic surgery of the defect using fasciocutaneous flap</kwd><kwd>neopharynx</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>местно-распространенный рак шейного отдела пищевода</kwd><kwd>плоскоклеточный рак пищевода</kwd><kwd>хирургическое лечение пищевода</kwd><kwd>резекция шейного отдела пищевода</kwd><kwd>пластика дефекта лучевым кожно-фасциальным лоскутом</kwd><kwd>неофарингс</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Mendenhall W.M., Sombeck M.D., Parsons J.T. et al. Management of cervical esophageal carcinoma. Semin Radiat Oncol 1994;4(3):179–91. DOI: 10.1053/SRAO00400179.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Collin C.F., Spiro R.H. Carcinoma of the cervical esophagus: changing therapeutic trends. Am J Surg 1984;148(4):460–6. DOI: 10.1016/0002-9610(84)90370-2.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Jones A.S., Roland N.J., Hamilton J. et al. Malignant tumours of the cervical esophagus. Clin Otolaryngol Allied Sci 1996;21(1):49–53. DOI: 10.1111/j.1365-2273.1996.tb01024.x.</mixed-citation></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Tryakin A.A., Besova N.S., Volkov N.M. et al. Practical recommendations for the drug treatment of cancer of the esophagus and esophageal-gastric junction. Zlokachestvenniye opukholy = Malignant tumors 2021;11(3s2–1):299–313. DOI: 10.18027/2224-5057-2021-11-3s2-20.</mixed-citation><mixed-citation xml:lang="ru">Трякин А.А., Бесова Н.С., Волков Н.М. и др. Практические рекомендации по лекарственному лечению рака пищевода и пищеводно-желудочного перехода. Злокачественные опухоли 2021;11(3s2–1):299–313. DOI: 10.18027/2224-5057-2021-11-3s2-20.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><mixed-citation>Tong D.K., Law S., Kwong D.L. et al. Current management of cervical esophageal cancer. World J Surg 2011;35(3):600–7. DOI: 10.1007/s00268-010-0876-7.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Saeki H., Tsutsumi S., Yukaya T. et al. Clinicopathological features of cervical esophageal cancer: retrospective analysis of 63 consecutive patients who underwent surgical resection. Ann Surg 2017;265(1):130–6. DOI: 10.1097/SLA.0000000000001599.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Takebayashi K., Tsubosa Y., Matsuda S. et al. Comparison of curative surgery and definitive chemoradiotherapy as initial treatment for patients with cervical esophageal cancer. Dis Esophagus 2017;30(2):1–5 DOI: 10.1111/dote.12502.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Burmeister B.H., Smithers B.M., Gebski V. et al. Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial. Lancet Oncol 2005;6(9):659–68. DOI: 10.1016/S1470-2045(05)70288-6.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Urba S.G., Orringer M.B., Turrisi A. et al. Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol 2001;19(2):305–13. DOI: 10.1200/JCO.2001.19.2.305.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Sun F., Li X., Lei D. et al. Surgical management of cervical esophageal carcinoma with larynx preservation and reconstruction. Int J Clin Exp Med 2014;7(9):2771–8. PMID: 25356138. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211788/pdf/ijcem0007-2771.pdf?xtrsl=en&amp;xtrtl=ru&amp;xtrhl=ru&amp;xtrpto=op,sc.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Bosset J.F., Gignoux M., Triboulet J.P. et al. Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. N Engl J Med 1997;337(3):161–7. DOI: 10.1056/NEJM199707173370304.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Le Prise E., Etienne P.L., Meunier B. et al. A randomized study of chemotherapy, radiation therapy, and surgery versus surgery for localized squamous cell carcinoma of the esophagus Cancer 1994;73(7):1779–84. DOI: 10.1002/1097-0142(19940401)73:7&lt;1779::aid-cncr2820730702&gt;3.0.co;2-t.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Apinop C., Puttisak P., Preecha N. A prospective study of combined therapy in esophageal cancer. Hepatogastroenterology 1994;41(4):391–3.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Nygaard K., Hagen S., Hansen H.S. et al. Pre-operative radiotherapy prolongs survival in operable esophageal carcinoma: a randomized, multicenter study of preoperative radiotherapy and chemotherapy. The second Scandinavian trial in esophageal cancer. World J Surg 1992;16(6):1104–10. DOI: 10.1007/BF02067069.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Walsh T.N., Noonan N., Hollywood D. et al. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med 1996;335(7):462–7. DOI: 10.1056/NEJM199608153350702.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Tekin S., Engin Y., Lutfi E. Pharyngoesophageal reconstruction with the radial forearm free flap. J Exp Clin Med 2016;33(4):199204. DOI: 10.5835/jecm.omu.33.04.004.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Harii K., Ebihara S., Ono I. et al. Pharyngoesophageal reconstruction using a fabricated forearm free flap. Plast Reconstr Surg 1985;75(4):463–76. DOI: 10.1097/00006534-198504000-00001.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Taylor S.M., Haughey B.H. Combined pharyngoesophageal and cervical skin reconstruction using a single radial forearm flap. Laryngoscope 2002;112(7 Pt 1):1315–8. DOI: 10.1097/00005537-200207000-00032.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Tornero J., Cruz-Toro P., Farré A. et al. [Free radial forearm flap in head and neck: our experience (In Spanish)]. Acta Otorrinolaringol Esp 2014;65(1):27–32. DOI: 10.1016/j.otorri.2013.09.003.</mixed-citation></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">Piazza C., Taglietti V., Nicolai P. Reconstructive options after total laryngectomy with subtotal or circumferential hypopharyngectomy and cervical esophagectomy. Curr Opin Otolaryngol Head Neck Surg 2012;20(2):77–88. DOI:10.1097/MOO.0b013e328350a5cc.</mixed-citation><mixed-citation xml:lang="ru">Piazza C., Taglietti V., Nicolai P. Reconstructive options after total laryngectomy with subtotal or circumferential hypopharyngectomy and cervical esophagectomy. Curr Opin Otolaryngol Head Neck Surg 2012;20(2):77–88. 10.1097/MOO.0b013e328350a5cc.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><mixed-citation>Tan N.C., Lin P.Y., Kuo P.J. et al. An objective comparison regarding rate of fistula and stricture among anterolateral thigh, radial forearm, and jejunal free tissue transfers in circumferential pharyngo-esophageal reconstruction. Microsurg 2015;35(3): 345–9. DOI: 10.1002/micr.22359.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Dodd A.R., Goodnight J.E., Pu L.L. Successful management of cervicoesophageal anastomosis leak after microsurgical esophageal reconstruction: a case report and review of the literature. Ann Plast Surg 2010;65(1):110–4. DOI: 10.1097/SAP.0b013e3181c51f7a.</mixed-citation></ref></ref-list></back></article>
