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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">MD-Onco</journal-id><journal-title-group><journal-title xml:lang="en">MD-Onco</journal-title><trans-title-group xml:lang="ru"><trans-title>MD-Onco</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2782-3202</issn><issn publication-format="electronic">2782-6171</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">40</article-id><article-id pub-id-type="doi">10.17650/2782-3202-2022-2-3-16-20</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>RARE NEOPLASMS: COMPLEX CLINICAL SITUATIONS AND SELECTION OF TREATMENT TACTICS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>РЕДКИЕ НОВООБРАЗОВАНИЯ: СЛОЖНЫЕ КЛИНИЧЕСКИЕ СИТУАЦИИ И ВЫБОР ТАКТИКИ ЛЕЧЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Successful combination treatment of metastatic ductal carcinoma of the pancreas tail pT4N0M1(per). Clinical case</article-title><trans-title-group xml:lang="ru"><trans-title>Успешное комбинированное лечение метастатического протокового рака хвоста поджелудочной железы pT4N0M1(per). Клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4108-9956</contrib-id><name-alternatives><name xml:lang="en"><surname>Glukhov</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Глухов</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><bold>Evgeny V. Glukhov</bold> </p><p><italic>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</italic></p></bio><bio xml:lang="ru"><p><bold>Евгений Вячеславович Глухов</bold> </p><p><italic>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111 </italic></p></bio><email>drgluhov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5038-9307</contrib-id><name-alternatives><name xml:lang="en"><surname>Davydov</surname><given-names>M. M.</given-names></name><name xml:lang="ru"><surname>Давыдов</surname><given-names>М. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</italic></p></bio><bio xml:lang="ru"><p><italic>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111 </italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6836-4028</contrib-id><name-alternatives><name xml:lang="en"><surname>Ivanov</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Иванов</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</italic></p></bio><bio xml:lang="ru"><p><italic>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111 </italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Filatov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Филатов</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</italic></p></bio><bio xml:lang="ru"><p><italic>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111 </italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shogenov</surname><given-names>M. S.</given-names></name><name xml:lang="ru"><surname>Шогенов</surname><given-names>М. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</italic></p></bio><bio xml:lang="ru"><p><italic>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111 </italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9361-6354</contrib-id><name-alternatives><name xml:lang="en"><surname>Dementieva</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Дементьева</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</italic></p></bio><bio xml:lang="ru"><p><italic>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111 </italic></p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Clinical Hospital “Lapino” of the “Mother and Child” Group of companies</institution></aff><aff><institution xml:lang="ru">Клинический госпиталь «Лапино» группы компаний «Мать и дитя»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-10-13" publication-format="electronic"><day>13</day><month>10</month><year>2022</year></pub-date><volume>2</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>16</fpage><lpage>20</lpage><history><date date-type="received" iso-8601-date="2022-10-13"><day>13</day><month>10</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-10-13"><day>13</day><month>10</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, ABV-Press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, АБВ-пресс</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">ABV-Press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://mdonco.abvpress.ru/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://mdonco.abvpress.ru/jour/article/view/40">https://mdonco.abvpress.ru/jour/article/view/40</self-uri><abstract xml:lang="en"><p>Pancreatic tail cancer has a poor prognosis and may be unresectable at the time of diagnosis, since it is asymptomatic and often has invasion into adjacent organs, and also has a high metastatic potential, where the target organs are the liver, lungs, bones, as well as the parietal and visceral peritoneum, adrenal glands. Radical resection of the pancreas in such cases is impractical. The gold standard of treatment is systemic chemotherapy. We describe the successful resection of locally advanced pancreatic tail cancer with metastases along the peritoneum of the large omentum after 14 courses of chemotherapy according to the mFOLFIRINOX (oxaliplatin 85 mg/m<sup>2</sup> intravenously for 120 min, irinotecan 150 mg/m<sup>2</sup> intravenously for 90 min, leucovorin 400 mg/m<sup>2</sup> intravenously for 120 min, 5-fluorouracil 2400 mg/m<sup>2</sup> intravenous infusion for 46 hours, cycle 14 days).</p></abstract><trans-abstract xml:lang="ru"><p>Рак хвоста поджелудочной железы длительное время протекает бессимптомно, часто диагностируется в местно-распространенной нерезектабельной или метастатической стадии, нередко имеет инвазию в смежные органы, а также обладает высоким метастатическим потенциалом, при этом органами-мишенями являются печень, легкие, кости, а также париетальная и висцеральная брюшина, надпочечники, что обусловливает плохой прогноз. Радикальные резекции поджелудочной железы в таких случаях нецелесообразны. «Золотым стандартом» лечения является системная химиотерапия. В данной статье приводится пример успешной резекции местно-распространенного рака хвоста поджелудочной железы с метастазом по брюшине большого сальника после 14 курсов полихимиотерапии по схеме mFOLFIRINOX (оксалиплатин 85мг/м<sup>2</sup> внутривенно в течение 120 мин, иринотекан 150мг/м<sup>2</sup> внутривенно в течение 90 мин, лейковорин 400 мг/м<sup>2</sup> внутривенно в течение 120 мин, 5-фторурацил 2400 мг/м<sup>2</sup> внутривенная инфузия в течение 46 ч, цикл 14 дней).</p></trans-abstract><kwd-group xml:lang="en"><kwd>pancreatic cancer</kwd><kwd>metastasis</kwd><kwd>chemotherapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак поджелудочной железы</kwd><kwd>метастаз</kwd><kwd>полихимиотерапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. GLOBOCAN: cancer incidence and mortality worldwide in 2020. 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