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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">MD-Onco</journal-id><journal-title-group><journal-title xml:lang="en">MD-Onco</journal-title><trans-title-group xml:lang="ru"><trans-title>MD-Onco</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2782-3202</issn><issn publication-format="electronic">2782-6171</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">51</article-id><article-id pub-id-type="doi">10.17650/2782-3202-2022-2-4-22-26</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>RARE NEOPLASMS: COMPLEX CLINICAL SITUATIONS AND SELECTION OF TREATMENT TACTICS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>РЕДКИЕ НОВООБРАЗОВАНИЯ: СЛОЖНЫЕ КЛИНИЧЕСКИЕ СИТУАЦИИ И ВЫБОР ТАКТИКИ ЛЕЧЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Difficulties of diagnosis and characteristics of clinical progression of anaplastic thyroid cancer. Clinical case</article-title><trans-title-group xml:lang="ru"><trans-title>Сложности диагностики и особенности клинического течения анапластического рака щитовидной железы. Клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0918-3857</contrib-id><name-alternatives><name xml:lang="en"><surname>Mudunov</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Мудунов</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081; Bld. 2, 8 Trubetskaya St., Moscow 119991</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111; 119991 Москва, ул. Трубецкая, 8, стр. 2</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1448-1733</contrib-id><name-alternatives><name xml:lang="en"><surname>Pkheshkhova</surname><given-names>B. G.</given-names></name><name xml:lang="ru"><surname>Пхешхова</surname><given-names>Б. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081; 6 Miklukho-Maklaya St., Moscow 117198</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111; 117198 Москва, ул. Миклухо-Маклая, 6</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1564-424X</contrib-id><name-alternatives><name xml:lang="en"><surname>Zeynalova</surname><given-names>P. A.</given-names></name><name xml:lang="ru"><surname>Зейналова</surname><given-names>П. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081; Bld. 2, 8 Trubetskaya St., Moscow 119991</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111; 119991 Москва, ул. Трубецкая, 8, стр. 2</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4927-5585</contrib-id><name-alternatives><name xml:lang="en"><surname>Fedenko</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Феденко</surname><given-names>А. A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1794-7247</contrib-id><name-alternatives><name xml:lang="en"><surname>Batsev</surname><given-names>A. F.</given-names></name><name xml:lang="ru"><surname>Бацев</surname><given-names>А. Ф.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4546-0011</contrib-id><name-alternatives><name xml:lang="en"><surname>Pak</surname><given-names>M. B.</given-names></name><name xml:lang="ru"><surname>Пак</surname><given-names>М. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Maksim B. Pak.</p><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081; Bld. 2, 8 Trubetskaya St., Moscow 119991</p></bio><bio xml:lang="ru"><p>Пак Максим Бокманович.</p><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111; 119991 Москва, ул. Трубецкая, 8, стр. 2</p></bio><email>mbpak@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Clinical Hospital “Lapino” of the “Mother and Child” Group of companies</institution></aff><aff><institution xml:lang="ru">Клинический госпиталь «Лапино» группы компаний «Мать и дитя»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">RUDN University</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский университет дружбы народов»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-12-14" publication-format="electronic"><day>14</day><month>12</month><year>2022</year></pub-date><volume>2</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>22</fpage><lpage>26</lpage><history><date date-type="received" iso-8601-date="2022-11-01"><day>01</day><month>11</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-12-13"><day>13</day><month>12</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, ABV-Press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, АБВ-пресс</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">ABV-Press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://mdonco.abvpress.ru/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://mdonco.abvpress.ru/jour/article/view/51">https://mdonco.abvpress.ru/jour/article/view/51</self-uri><abstract xml:lang="en"><p>The article describes clinical observation of locally advanced metastatic anaplastic thyroid cancer. Difficulties in instrumental and laboratory diagnosis of this pathology and the role of molecular diagnosis in search for highly effective treatment are discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Статья посвящена клиническому наблюдению местно-распространенного метастатического анапластического рака щитовидной железы. Освещены сложности инструментальной и лабораторной диагностики данной патологии, а также роль молекулярной диагностики в поиске высокоэффективного лечения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>anaplastic cancer</kwd><kwd>thyroid cancer</kwd><kwd>thyroid cancer diagnosis</kwd><kwd>BRAF mutation in thyroid cancer</kwd><kwd>PD-L1</kwd><kwd>molecular diagnosis of thyroid cancer</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>анапластический рак</kwd><kwd>рак щитовидной железы</kwd><kwd>диагностика рака щитовидной железы</kwd><kwd>BRAF-мутированный рак щитовидной железы</kwd><kwd>PD-L1</kwd><kwd>молекулярная диагностика рака щитовидной железы</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1.	Ragazzi M., Ciarrocchi A., Sancisi V. et al. Update on anaplastic thyroid carcinoma: morphological, molecular, and genetic features of the most aggressive thyroid cancer. 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