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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">MD-Onco</journal-id><journal-title-group><journal-title xml:lang="en">MD-Onco</journal-title><trans-title-group xml:lang="ru"><trans-title>MD-Onco</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2782-3202</issn><issn publication-format="electronic">2782-6171</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">56</article-id><article-id pub-id-type="doi">10.17650/2782-3202-2022-2-4-56-62</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>NEW APPROACHES AND SUCCESSES IN TREATMENT OF ONCOLOGICAL PATIENTS AT THE CURRENT STAGE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>НОВЫЕ НАПРАВЛЕНИЯ И УСПЕХИ В ЛЕЧЕНИИ ОНКОЛОГИЧЕСКИХ БОЛЬНЫХ НА СОВРЕМЕННОМ ЭТАПЕ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">A case of combination treatment of femoral osteosarcoma</article-title><trans-title-group xml:lang="ru"><trans-title>Случай комбинированного лечения остеосаркомы бедренной кости</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5842-244X</contrib-id><name-alternatives><name xml:lang="en"><surname>Filimonov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Филимонов</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Aleksiy A. Filimonov.</p><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>Филимонов Алексий Алексеевич.</p><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><email>aleksii.f.cz@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0103-446X</contrib-id><name-alternatives><name xml:lang="en"><surname>Kutakov</surname><given-names>N. M.</given-names></name><name xml:lang="ru"><surname>Кутаков</surname><given-names>Н. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chekini</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Чекини</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Musaev</surname><given-names>E. M.</given-names></name><name xml:lang="ru"><surname>Мусаев</surname><given-names>Э. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Akhov</surname><given-names>A. O.</given-names></name><name xml:lang="ru"><surname>Ахов</surname><given-names>А. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5353-8857</contrib-id><name-alternatives><name xml:lang="en"><surname>Zhukov</surname><given-names>A. G.</given-names></name><name xml:lang="ru"><surname>Жуков</surname><given-names>А. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6229-7300</contrib-id><name-alternatives><name xml:lang="en"><surname>Timofeeva</surname><given-names>O. L.</given-names></name><name xml:lang="ru"><surname>Тимофеева</surname><given-names>О. Л.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2359-0547</contrib-id><name-alternatives><name xml:lang="en"><surname>Abbasbeyli</surname><given-names>F. M.</given-names></name><name xml:lang="ru"><surname>Аббасбейли</surname><given-names>Ф. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8443-8816</contrib-id><name-alternatives><name xml:lang="en"><surname>Ryabukhina</surname><given-names>Yu. E.</given-names></name><name xml:lang="ru"><surname>Рябухина</surname><given-names>Ю. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1564-424X</contrib-id><name-alternatives><name xml:lang="en"><surname>Zeynalova</surname><given-names>P. A.</given-names></name><name xml:lang="ru"><surname>Зейналова</surname><given-names>П. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4927-5585</contrib-id><name-alternatives><name xml:lang="en"><surname>Fedenko</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Феденко</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8361-6200</contrib-id><name-alternatives><name xml:lang="en"><surname>Ibragimov</surname><given-names>E. K.</given-names></name><name xml:lang="ru"><surname>Ибрагимов</surname><given-names>Э. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1<sup>st</sup> Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Clinical Hospital “Lapino” of the “Mother and Child” Group of companies</institution></aff><aff><institution xml:lang="ru">Клинический госпиталь «Лапино» группы компаний «Мать и Дитя»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-12-14" publication-format="electronic"><day>14</day><month>12</month><year>2022</year></pub-date><volume>2</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>56</fpage><lpage>62</lpage><history><date date-type="received" iso-8601-date="2022-11-07"><day>07</day><month>11</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-12-14"><day>14</day><month>12</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, ABV-Press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, АБВ-пресс</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">ABV-Press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://mdonco.abvpress.ru/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://mdonco.abvpress.ru/jour/article/view/56">https://mdonco.abvpress.ru/jour/article/view/56</self-uri><abstract xml:lang="en"><p>Osteosarcomas are rare tumors with aggressive biology. It is important to refer such patients to a high-volume center, where an accurate diagnosis and optimal treatment are more likely to be performed. In contrast to Ewing's sarcoma, conventional osteosarcomas are believed to be generally resistant to radiation therapy, and the main treatment modalities are surgery and chemotherapy. In this clinical case, we demonstrate the efficacy of combined treatment of osteosarcoma of the femur.</p><p>Preoperative chemotherapy allowed to evaluate tumor sensitivity to systemic treatment in vivo and optimize adjuvant treatment after R0 resection which allowed to achieve complete clinical response to treatment.</p></abstract><trans-abstract xml:lang="ru"><p>Остеосаркомы представляют собой редкие опухоли с агрессивной биологией, при подозрении на которые важно направить пациента в референсный центр, где постановка точного диагноза и выработка оптимальной тактики лечения наиболее вероятны. В отличие от саркомы Юинга остеосаркома традиционно считается резистентной к лучевой терапии, и основными компонентами полноценного лечения являются радикальное хирургическое вмешательство и химиотерапия. В представленном клиническом случае продемонстрирована эффективность комбинированного лечения остеосаркомы бедренной кости. Проведение предоперационной химиотерапии позволило оценить чувствительность опухоли к системному лечению in vivo и оптимизировать адъювантную терапию после выполнения RO-резекции, что способствовало достижению полного клинического ответа на лечение.</p></trans-abstract><kwd-group xml:lang="en"><kwd>osteosarcoma</kwd><kwd>bone sarcoma</kwd><kwd>combined treatment</kwd><kwd>bone resection</kwd><kwd>chemotherapy</kwd><kwd>port systems</kwd><kwd>infusion pumps</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>остеосаркома</kwd><kwd>саркома кости</kwd><kwd>комбинированное лечение</kwd><kwd>резекция кости</kwd><kwd>химиотерапия</kwd><kwd>порт-системы</kwd><kwd>инфузионные помпы</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Gatta G., Capocaccia R., Botta L. et al. Burden and centralised treatment in Europe of rare tumours: results of RARECAREnet-a population-based study. Lancet Oncol 2017;18(8):1022-39. 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