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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">MD-Onco</journal-id><journal-title-group><journal-title xml:lang="en">MD-Onco</journal-title><trans-title-group xml:lang="ru"><trans-title>MD-Onco</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2782-3202</issn><issn publication-format="electronic">2782-6171</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">85</article-id><article-id pub-id-type="doi">10.17650/2782-3202-2023-3-4-35-40</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>NEW DIRECTIONS AND ADVANCEMENTS IN TREATMENT OF ONCOLOGICAL DISEASES IN THE CURRENT AGE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>НОВЫЕ НАПРАВЛЕНИЯ И УСПЕХИ В ЛЕЧЕНИИ ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ НА СОВРЕМЕННОМ ЭТАПЕ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Transcatheter prosthetics in post-radiation aortic stenosis: a review of literature</article-title><trans-title-group xml:lang="ru"><trans-title>Транскатетерное протезирование при постлучевом аортальном стенозе: обзор литературы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6395-5790</contrib-id><name-alternatives><name xml:lang="en"><surname>Akhobekov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Ахобеков</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Albert Amalievich Akhobekov</p><p>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>Альберт Амалиевич Ахобеков</p><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><email>alber-t7@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1564-424X</contrib-id><name-alternatives><name xml:lang="en"><surname>Zeynalova</surname><given-names>P. A.</given-names></name><name xml:lang="ru"><surname>Зейналова</surname><given-names>П. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</p><p>Bld. 2, 8 Trubetskaya St., Moscow 119991</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p><p>119991 Москва, ул. Трубецкая, 8, стр. 2</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8443-8816</contrib-id><name-alternatives><name xml:lang="en"><surname>Ryabukhina</surname><given-names>Yu. E.</given-names></name><name xml:lang="ru"><surname>Рябухина</surname><given-names>Ю. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8581-1328</contrib-id><name-alternatives><name xml:lang="en"><surname>Chekini</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Чекини</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>111 1st Uspenskoe Shosse, Lapino, Moscow region 143081</p></bio><bio xml:lang="ru"><p>143081 Московская обл., д. Лапино, 1-е Успенское шоссе, 111</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Clinical Hospital “Lapino” of the “Mother and Child” Group of companies</institution></aff><aff><institution xml:lang="ru">Клинический госпиталь «Лапино» группы компаний «Мать и дитя»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-12-07" publication-format="electronic"><day>07</day><month>12</month><year>2023</year></pub-date><volume>3</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>35</fpage><lpage>40</lpage><history><date date-type="received" iso-8601-date="2023-12-07"><day>07</day><month>12</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-12-07"><day>07</day><month>12</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, ABV-Press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, АБВ-пресс</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">ABV-Press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://mdonco.abvpress.ru/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://mdonco.abvpress.ru/jour/article/view/85">https://mdonco.abvpress.ru/jour/article/view/85</self-uri><abstract xml:lang="en"><p>Aortic stenosis belongs to the most common acquired cardiac defects in adults, affecting about 2 % of those over 65 years old and 4 % of those over 85 years old. One of the common causes of aortic stenosis is radiation therapy of the mediastinum for malignant neoplasms localised in the thorax. According to the American Society of Clinical Oncology, 10–30 % of patients receiving radiation therapy tend to develop cardiovascular complications, usually after an average follow-up period of 5 to 10 years. About 80 % of cardiovascular complications of radiation therapy are valve diseases, aortic stenosis accounting for a significant part of them. Radiation causes late cicatrisation, fibrous thickening, retraction and calcification of aortic valve cusps, contributing to the restriction of their movement and therefore to the narrowing of the aortic valve orifice. Patients with aortic valve stenosis have an average lifespan of about 3 years after coronary symptoms or syncopal conditions appear, and about 1.5 years after congestive heart failure begins to manifest. Aortic valve prosthetics is the sole effective and radical treatment method for patients with aortic valve stenosis that allows to improve their condition and prolong their life. Transcatheter aortic valve prosthetics are the treatment of choice in this category of patients.</p></abstract><trans-abstract xml:lang="ru"><p>Аортальный стеноз – один из самых распространенных видов приобретенных пороков сердца у взрослых. Около 2 % людей старше 65 лет и 4 % людей старше 85 лет страдают данной патологией. Одной из частых причин развития аортального стеноза является лучевая терапия с облучением средостения по поводу злокачественных новообразований, локализующихся в области грудной клетки. По данным Американского общества клинической онкологии, сердечно-сосудистые осложнения имеют тенденцию к развитию у 10–30 % пациентов, получающих лучевую терапию, обычно после среднего периода наблюдения от 5 до 10 лет. Среди сердечно-сосудистых осложнений лучевой терапии клапанные болезни составляют около 80 %, и значительная их часть представлена аортальным стенозом. Лучевое воздействие приводит к позднему рубцеванию, фиброзному утолщению, ретракции и кальцификации створок аортального клапана, что способствует ограничению их движения и, как следствие, сужению отверстия аортального клапана. Средняя продолжительность жизни больных со стенозом аортального клапана после появления коронарной симптоматики или синкопальных состояний составляет примерно 3 года, а от начала проявлений застойной сердечной недостаточности – около полутора лет. Протезирование аортального клапана – единственный эффективный и радикальный метод лечения пациентов с аортальным стенозом, позволяющий улучшить состояние и продлить жизнь больного. Транскатетерные методы протезирования аортального клапана являются методом выбора в лечении данной категории больных.</p></trans-abstract><kwd-group xml:lang="en"><kwd>aortic stenosis</kwd><kwd>aortic valve prosthetics</kwd><kwd>transcatheter aortic valve prosthetics</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аортальный стеноз</kwd><kwd>протезирование аортального клапана</kwd><kwd>транскатетерное протезирование аортального клапана</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Stewart B.F., Siscovick D., Lind B.K. et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol 1997;29(3):630–4. DOI: 10.1016/s0735-1097(96)00563-3</mixed-citation></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Egorov I.V. Secondary calcification of intracardiac structures. 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